Signs and Symptoms of Acromegaly

Here is a list of signs and symptoms that may or may not apply to you. For those that apply to you, you may want to discuss them with your endocrinologist. 

1. Signs and symptoms linked to GH/IGF-1 excess:

  • Changes in facial features
  • Soft tissue swelling of tongue and lips
  • Deepening of the voice
  • Snoring
  • Enlargement of feet and hands
  • Protrusion of the jaw
  • Teeth gap
  • Excessive sweating
  • Thickening and oily skin
  • Acne and skin tags
  • Joint pain/arthritis
  • Carpal Tunnel Syndrome
  • Enlarged organs: thyroid, liver, spleen, heart 

2. Signs and symptoms linked to mass effects of the adenoma:

  • Headaches
  • Visual disturbances
  • Cranial nerve palsies (facial pain, eyelid drooping and double vision)
  • Hypopituitarism with menstrual disorders, decreased libido, infertility, erectile dysfunction, hypothyroidism, fatigue, and muscle weakness 

3. Signs and symptoms linked to prolactin co-secretion:

  • Menstrual disorders
  • Decreased libido
  • Infertility
  • Erectile dysfunction
  • Galactorrhea (milk production)
  • Gynecomastia (breast enlargement) 

4. Complications linked to acromegaly:

  • Diabetes
  • Heart disease
  • Hypertension
  • Sleep apnea (when you temporarily stop breathing while you are asleep)
  • Nasal polyps
  • Colon polyps
  • Mood swings

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